Sociodemographic and clinical characterization in hospital discharges of patients diagnosed with epilepsy Chile 2015-2019. Hospital discharges due to epilepsy in Chile

Vilma Martínez-Hernández, Romina Mora-Salgado, Patricio Oliva-Moresco, Jacqueline Araneda-Flores


Introduction: Epilepsy is a chronic neurological pathology that causes psychological and neuro-cognitive alterations and affects socioeconomic aspects, which makes it an important public health problem. Objective: To describe sociodemographic and clinical characteristics in hospital discharges of patients diagnosed with epilepsy in Chile during the 2015-2019 five-year period. Method: Descriptive cross-sectional study. The Statistical Report of Hospital Discharges of the Ministry of Health of Chile was used, a single database was constructed based on the records of hospital discharges diagnosed with epilepsy. (G.40). Results: 57.8% of hospital discharges corresponded to men and the age range of 45 to 59 years represented the highest proportion. At the national level, the majority health forecast was FONASA with 84.8%, a figure similar to that of care in public health establishments. The classification of unspecified type epilepsy (G40.9) was the most prevalent, the average days of hospitalization was 7.6 days, with a mortality rate of 6.3 per 1,000 hospital discharges and a hospitalization rate of 15.7 per 100,000 inhabitants. Conclusion: From the neurological diseases, epilepsy is the most frequent pathology of hospital discharges nationwide, with a higher incidence in adulthood, which is not consistent with the existing literature where a higher prevalence is noted in childhood and the elderly. It is pertinent to note that Chile has a long hospital stay when compared with other countries in the region.


Key words: Epilepsy, hospitalization, patient discharge.


The epidemiological transition that Chile experienced for more than three decades has become of interest due to the increase in non-communicable diseases, changes in mortality and morbidity patterns, and longer life expectancy, which has led to a growing demand for public and private health services(1). Hospital discharge rates are an indicator that enables the prioritization of economic costs and a response to user


Epilepsy is the second most frequent neurological disease worldwide with 72.5% of primary care consultations(3). It requires transdisciplinary care because it causes many cerebral sequelae and has physical, mental, and emotional repercussions on user quality of life(4). Worldwide, 45.9 million people with active epilepsy have been reported, and the age-standardized prevalence is 621.5 per 100,000 inhabitants(5).


Among the sociodemographic characteristics, age is related to an unfavorable evolution of the epileptic condition; it is a predictive factor, including for mortality(6), From a social perspective, there is evidence of bidirectional association between epilepsy and poverty; it has also been identified that race and economic status are



Clinical variables mainly include the type of epilepsy, age of onset, number of crises, and associated comorbidities(7). A study of subjects with epilepsy conducted in Colombia reported that 40% showed cognitive impairment and 18% psychiatric comorbidities. In addition, 37% exhibited resistance to drugs, while 14% had undergone epilepsy surgery(8).


Clinical research has focused its efforts on understanding crises in the prehospital setting. However, the need arises to identify characteristics of hospital stays because epilepsy is an increasingly recurrent emergency with significant health care costs(9).

Therefore, the objective of the present study was to describe sociodemographic and clinical characteristics of hospital discharges of users diagnosed with epilepsy in Chile between 2015 and 2019.


The descriptive cross-sectional study design was used. The source of information was the Informe Estadístico de Egresos Hospitalarios del Departamento de Estadísticas del Ministerio de Salud de Chile (Hospital Discharge Statistics Report of the Department of Statistics of the Chilean Ministry of Health,). An exclusive secondary database was constructed by recording all hospital discharges with an epilepsy diagnosis between 2015 and 2019. The records with an epilepsy diagnosis (G.40) and the variables of analysis were selected for a census sample of 14,436 discharges.


To eliminate distortion and minimize bias, hospital stays longer than 5 years (2 records) were excluded. The study was based on the ethical principles of the Declaration of Helsinki and was approved by the Bioethics and Biosecurity Committee of the Universidad del Bío-Bío.


Data were analyzed by descriptive statistics with the Excel program and SPSS v. 19 software. Measures of central tendency, position and/or dispersion were used for the quantitative variables. Meanwhile, measures of frequency and percentages were used for the qualitative variables.


In the 2015-2019 period, 14,436 discharges with an epilepsy diagnosis were recorded in Chile. Data analysis based on age group showed that the highest proportion of discharges was between 45 and 59 years of age with 25.5% (n = 3,681). The average age of hospitalization was 48 ± 23.5 years. The sex variable showed 57.82% (n = 8,347) men and 42.18% (n = 6,089) women.

The country was divided into three macrozones to analyze data for the region of residence variable. The macrozones were: northern (Arica and Parinacota, Tarapacá, Antofagasta, Atacama, and Coquimbo), central (Valparaíso, Metropolitan, Libertador General Bernardo O’Higgins, Maule, Ñuble, Biobío), and southern (Araucanía, Los Ríos, Los Lagos, Aysén del General Carlos Ibáñez del Campo, Magallanes and Chilean Antarctic, and Chileans Abroad) (Tables 1, 2, and 3). It should be noted that the northern and southern macrozones recorded lower nationwide discharge percentages, specifically in the Atacama and Aysén Regions with a value ? 1.4%. In contrast, in the central macrozone, the Metropolitan Region had the highest percentage with 26.4% (n = 3,808), followed by the Biobío Region with 13.8% (n = 1,997).

Table 4 shows that the trend for the five-year period is similar for the distribution of discharges by type of health insurance; the highest value was recorded for FONASA (National Health Fund) with 84.8% (n = 12,240). Accordingly, by type of facility, 83% (n = 12,041) of the subjects received care in public health facilities.


The epilepsy pathology in the Chilean Ministry of Health (MINSAL) database has been classified according to the International Classification of Diseases (ICD-10). This variable was analyzed in the present study according to sex (Figure 1), which revealed a higher proportion of men in all classifications, especially in the unspecified type with 43% (n = 6,215). For both sexes, 73.8% (n = 10,660) exhibited the same classification of unspecified epilepsy (G40.9). In contrast, the classifications with the lowest prevalence were unspecified grand mal (G40.6) with 0.5% (n = 72) and unspecified petit mal (G40.7) 0.1%

(n = 13).


There were 270 surgical procedures performed on hospitalized users, and there was a higher proportion in 2019 with 31.9% (n = 86). Overall, 24.4% (n = 66) of all surgeries were for epilepsy-specific procedures of which epilepsy and complex symptomatic epileptic syndrome (G40.2) accounted for 37.9% (n = 25).


In-hospital mortality represented 0.6% (n = 91) of users, while medical discharge was 99.4% (n = 14,345). The leading diagnosis resulting in mortality was unspecified epilepsy (G40.9) with 66% (n = 60).


Men had a higher mortality rate with 54.9% (n = 50) and average age of 63.6 years; the age group with the most records was between 75 and 89 years of age with 30.8% (n = 28). The in-hospital mortality rate for epilepsy was 6.3 per 1,000 discharges.

Finally, when analyzing the length of hospital stays, it was established that the average stay was 7.6 days. Likewise, the hospitalization rate for discharges was 15.7 per 100,000 inhabitants.


There was no correlation between the average age of hospitalization and age groups and the ages at which the prevalence and incidence of epilepsy were higher, although manifestations were more pronounced in children and the elderly(10). In the present study, the average age at admission to hospital was 48.4 ± 23.5 years. This is similar to findings reported in Peru for hospitalized patients with a slightly lower average age of 45.8 years(11).


The higher number of hospitalizations in adults could be explained by their being of working age and, together with justifying poor self-care practices, they are less committed to the disease, which leads to more frequent decompensations(12). In addition, other factors arise during the transition process from pediatric to adult care that could have an impact on higher records such as poorly personalized care, irregular check-ups, professionals with limited experience, and inadequate management of comorbidities(13).


When analyzing discharges in relation to the sex variable, there was a higher proportion of hospitalizations for men; this is similar to a study conducted in Ecuador that reported a slightly lower value of 52% of discharges(14). It has also been described that men have a higher incidence and susceptibility to convulsions, which could eventually be the cause of a higher record of hospitalizations(15).


The distribution of results by region of residence was consistent with population density. The largest number of records was in the Metropolitan Region, which shows that the high demand was matched by the greater supply of public and private health centers. This circumstance is similar to that of the Biobío and Valparaíso Regions(16).

Likewise, the extreme regions of the country had the lowest number of hospitalization records, which reflects possible geographic and socioeconomic inequalities(17). This situation has been supported by a study conducted in Brazil, which indicated that individuals with lower incomes were more likely to suffer severe crises due to sociocultural deprivation and comorbidities(18).


The health insurance variable and type of health care facility were consistent with the national reality because 78% of the population had FONASA health insurance in 2017(19). However, this result does not concur with a study conducted in Colombia in which the insurance benefits for this diagnosis were focused on private institutions with values between 66% and 83% of the demands for hospitalization(20).


As for epilepsy classifications, the largest number of hospitalization records showed unspecified epilepsy (G40.9). This fact could be explained by the existing shortcomings in diagnostic skills and difficulties in distinguishing the disease from other types of crises such as psychogenic seizures, syncope, sleep and movement disorders, and the different types of epilepsy(20).


Furthermore, this is reinforced by the discrepancy between the types of epilepsy established by the International Classification of Diseases (ICD-10) and those proposed by the International League Against Epilepsy(21). This occurs because the ICD-10 classifications are outdated and use obsolete terminology such as petit and grand mal(21).


Given that convulsions are often unobserved by third parties, are atypical, or have subtle manifestations, the diagnosis is often unspecific(22,23). It is estimated that 20% of users in Spain with uncontrolled crises are misdiagnosed due to ignored, trivialized, or poorly defined symptoms(24).


It should be mentioned that while the diagnosis of epilepsy and symptomatic epileptic syndromes (G40.2) was not the classification with the highest hospitalization rates, it recorded the highest number of surgeries. This is explained by the fact that it is a type of epilepsy related to focal localizations and complex partial seizures, which makes surgery more effective and safer and provides a greater possibility of recovery and seizure control(25).


Of all the performed surgical procedures, there was no record of mortality due to surgery for epilepsy; this emphasized the fact that despite the high cost of this type of procedure, it is offset by reduced long-term economic costs. This is reflected in a study conducted in the U.S. population, which showed an annual decrease of costs between US$6,806 and US$13,454(26). A study in the United Kingdom included 284 users who underwent surgery and 47% and 38% remained seizure-free for 5 and 10 years, respectively, after the procedure(27).


Although epilepsy surgery is recognized as a safe and effective procedure, the proportion of users who do not receive surgical management is significantly higher in developing countries (one-fifth of low- and middle-income countries) than in developed countries. This situation is explained by socioeconomic factors and insufficient research on the impact of surgery in these countries(28,29).

The in-hospital mortality rate was similar to the value reported in a study in Ecuador with 6.2 per 1,000 discharges(30). Another study conducted in the public hospitals of Hong Kong consisted of 7,461 users; it reported that 29% (n = 2,166) died during the five-year study, which resulted in a standardized mortality rate of 5.09(31).


It should be noted that the lowest mortality rate occurred in 2019, and this value was not proportional to the number of hospitalizations because the highest number of discharges was recorded that year. This could be explained by the fact that in a hospital admission with varied symptomatology, all the necessary procedures can be performed to reduce the severity of the condition and thus in-hospital mortality(20).


The average hospital stay was 7.6 ± 25.6 days; this was higher than findings published in a study in the United States that reported an average of 3.83 days(32) and another in Colombia with an average of 4.91 days(33). Nonetheless, a study conducted in an epilepsy unit in the United States indicated a longer stay of 6.9 days for generalized symptomatic epilepsy(34).


Ecuador has reported an average hospital stay of 7.32 days(35), which is the closest approximation to the value obtained in the present study. This situation could be explained by the lack of specialized centers, shortage of specialists, and limited availability to conduct studies that would enable the health care system to provide optimal treatment(36).


The highest hospitalization rate occurred in 2019; this could be explained by improved record quality, changes in methodology or external variables such as the high cost of drugs and associated insurance benefits, which limit the continuity of care(13). The rate of 22.0 per 100,000 inhabitants was equivalent to 4,021 discharges, which is similar to 4,782 discharges recorded in Ecuador(35).


A study conducted in London indicated that epilepsy in the elderly is associated with increased hospitalization rates and longer hospital stays, both of which are predictors of a fatal outcome(37). However, the present study revealed that the elderly, despite a higher mortality rate, did not show higher hospitalization rates.


This study contributes hard data to reveal the nationwide context of an increasingly prevalent pathology. However, it is an obligation and scientific responsibility to recognize a limitation of the study related to the poor quality of the records and insufficient information on discharges. The data did not include clinical variables such as comorbidities, adherence to treatment, severity, and sociodemographic factors such educational attainment, marital status, and employment status. These data would enable a scientific analysis of greater health relevance and significance.


Based on the obtained information, it is feasible to draw conclusions with practical health benefits, including that epilepsy is the neurological disease with the most frequent records of hospital discharges nationwide. Its incidence is higher in adult age groups; this does not concur with the reviewed literature that reports a higher prevalence in childhood and the elderly. These records reflect the difficulty in controlling the disease and the complexity involved in adapting treatments.


The positive results in reducing mortality rates are grounds for maintaining the resources allocated to treat the disease. However, efforts must be directed at addressing the differences based on sex and regional inequalities. In addition, technological tools and therapeutic measures, such as surgical procedures, must evolve because they are still limited in the country.

Given that the present study is an initial approximation to the investigation of hospital discharges, it is suggested that further research be conducted to study in greater depth the characteristics of users and incorporate other types of variables related to any eventual hospitalization. This would enable continuity in improving the diagnostic approach through research methodologies based on the level of evidence that can support the implementation of new programs and public policies.


The identification of sociodemographic and clinical characteristics in hospital stays is an imperative action, given that epilepsy is an increasingly prevalent disease. It implies significant health costs due to the multiple effects it causes, mainly morbidity.


  • 1. Varela L. Salud y Calidad de vida en el adulto mayor. Rev Perú Med Exp Salud Pública. 2016; 33(2): 199-201.
  • 2. Ministerio de Salud. Departamento de Estadística e Información en Salud (DEIS). Manual de Sistema de Egresos Hospitalarios. Ministerio de Salud de Chile. Subsecretaría de Salud Pública. 5ta ed. 2018; 4-53.
  • 3. Del Busto J, Toledo L. Consideraciones en el tratamiento del paciente con epilepsia. Artículo de revisión. Rev Haban de Cienc Méd. 2017; 16(6): 912-926.
  • 4. Reyes I, Hernández J, Chumaceiro A, Cadrazco C. Epilepsia un abordaje social: experiencia de sensibilización y concientización ciudadana. Rev Cient de Cien Hum. 2016; 12(35): 58-76.
  • 5. Beghi E, Giussani G, Nichols E, Abd F, Abdela J, Abdelalim A, et al. Global,regional, and national burden of epilepsy, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019; 18(4): 357-375.
  • 6. Rivero D, Scherle C, Di Capua D, Jibaja M, Santacruz M, Mullo E, et al. Estatus Epiléptico. Factores Asociados a Una Evolución Desfavorable en un Centro Terciario. Rev Ecuat Neurol. 2018: 27(2); 25-30.
  • 7. Keezer M, Sisodiya S, Sander J. Comorbidities of epilepsy: current concepts and future perspectives. The Lancet Neurol. 2016; 15(1): 106-115.
  • 8. Orozco J, Quintero J, Marín D, Castaño J, Hernández P, Pineda M, et al. Perfil clínico y sociodemográfico de la epilepsia en adultos de un centro de referencia de Colombia. Neurol. 2019; 34(7): 437-444.
  • 9. Betjemann J, Lowenstein D. Status epilepticus in adults. Lancet Neurol. 2015; 14(6): 615-624.
  • 10. Helmers S, Thurman D, Durgin T, Pai A, Faught E. Descriptive epidemiology of epilepsy in the U.S. population: A different approach. Epilepsy. 2015; 56(6): 942-948.
  • 11. Graus J, Huerto J, Macavilca M, Nájar N, Rodríguez D. Factores clínicos y epidemiológicos relacionados a mortalidad en pacientes con estatus epiléptico en un hospital de Lima: una serie comparativa de casos. Rev Neuropsiquiatr. 2016; 79(4): 207-215.
  • 12. Galdames S, Jamet P, Bonilla A, Quintero F, Rojas V. Creencias sobre salud y prácticas de autocuidado en adultos jóvenes: estudio biográfico de estilos de vida. Hacia Promoc Salud. 2019; 24(1): 28-43.
  • 13. Franco D, Mora A, Muñoz G, Heresi C. Adolescentes con epilepsia en transición a la medicina de adultos. Rev chil pediatr. 2020; 91(5): 838-839.
  • 14. Benitez L. Factores de riesgo de epilepsia de pacientes atendidos en hospital básico Durán año 2017 [tesis]. Guayaquil: Facultad de Ciencias Médicas, Universidad de Guayaquil; 2018.
  • 15. Fiest K, Sauro K, Wiebe S, Patten S, Kwon C, Dykeman J, et al. Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies. Neurology. 2017; 88(3): 296-303.
  • 16. Rojas C, Astudillo P, Mancilla P. Dotación de camas hospitalarias del sector público en Chile: período 2008-2014. Medwave. 2016; 16(6): 6773.
  • 17. Instituto Nacional de Estadística INE. Estimaciones y Proyecciones a Nivel Regional de la Población de Chile 2002-2035. Chile Ed. 2017. 59
  • 18. Bacellar A, Pedreira B, Costa G, Assis T, Lobo C, Nascimento O. Predictors of readmission and long length of stay in elders admitted with neurological disorders in a tertiary center: a real-world investigation. Arq Neuro-Psiquiatr. 2019; 77(5): 321-329.
  • 19. Ministerio de Desarrollo Social. Encuesta CASEN. Salud: Síntesis de resultados Vol.2017, Encuesta de Caracterización Socioeconómica Nacional. 2018.
  • 20. Alonso M, Montoya C. Primera Crisis Epiléptica en Adultos: ¿Epilepsia o No? Rev Ecuat Neurol. 2019; 28(3): 68-72.
  • 21. Fisher S, Cross J, French A, Higurashi N, Hirsch E, Jansen E, et al. Clasificación operacional de los tipos de crisis por la Liga Internacional contra la Epilepsia: Documento-Posición de la Comisión para Clasificación y Terminología de la ILAE. Epilepsy. 2017; 58(4): 522-530.
  • 22. Motika P, Spencer D. Treatment of Epilepsy in the Elderly. Curr Neurol Neurosci Rep. 2016; 16(11): 96.
  • 23. Vu L, Piccenna L, Kwan P, O’Brien T. New-onset epilepsy in the elderly. Br J Clin Pharmacol. 2018; 84(10): 2208-2217.
  • 24. Servicio de Planificación de Programas y Servicios Sanitarios. Generalitat Valenciana. Consejería de Sanidad Universal y Salud Pública (ed.). Plan de atención a la Epilepsia en la comunidad Valenciana 2019-2023. Subdirección Gral. Planificación y Organización Asistencial. Dirección General de Asistencia Sanitaria. 2019.
  • 25. Barreto E, Villafuerte M, Becerra A, Díaz A, Hernández J, Llaja V. Cirugía resectiva de epilepsia lesional focal: Estudio en pacientes adultos del Seguro Social del Perú. Rev Neuropsiquiatr. 2017; 80(1): 12-21.
  • 26. Lopera M. Utilización de servicios de salud por enfermedades catastróficas o de alto costo en Antioquia. Rev Gerenc Polít Salud. 2017; 16(32): 120-137.
  • 27. Mohan M, Keller S, Nicolson A, Biswas S, Smith D, Osman J, et al. The long-term outcomes of epilepsy surgery. PLoS ONE 2018; 13(5): e0196274
  • 28. Ramírez E, de Font E, Terrazo J, González A, Collado M, Arch E, et al. Cirugía de epilepsia en el Centro Médico ABC. An Med (Mex). 2020; 65(3): 187-193.
  • 29. Watila M, Xiao F, Keezer M, Miserocchi A, Winkler A, McEvoy A, et al. Epilepsy surgery in low- and middle-income countries: A scoping review. Epilepsy Behav. 2019; 92: 311-326.
  • 30. Chaves J, Mancera O. Estatus Epiléptico en Colombia: Análisis Descriptivo de Serie de Casos. Rev Ecuat Neurol. 2017; 26(1): 9-16.
  • 31. Chen Z, Liew D, Kwan P. Excess mortality and hospitalized morbidity in newly treated epilepsy patients. Neurology. 2016; 87(7): 718-725.
  • 32. Patel R, Elmaadawi A, Mansuri Z, Kaur M, Shah K, Nasr S. Psychiatric Comorbidities and Outcomes in Epilepsy Patients: An Insight from a Nationwide Inpatient Analysis in the United States. Cureus. 2017; 9(9): 1686-1698.
  • 33. Legg K, Newton M. Counselling adults who experience a first seizure. Seizure. 2017; 49: 64-68.
  • 34. Gazzola D, Thawani S, Agbe O, Carlson C. Epilepsy monitoring unit length of stay. Epilepsy Behav. 2016; 58: 102-105.
  • 35. Ministerio de Salud Pública. Anuario de estadísticas de salud: camas y egresos hospitalarios. Registro estadístico de Egresos Hospitalarios 1995-2017. Instituto Nacional de Estadística y Censos INEC. Ecuador. 2019.
  • 36. Morales L. Las Epilepsias en la atención primaria de salud en América Latina. A propósito de un cuestionario. Rev chil epilepsia. 2016; 1: 4-11.
  • 37. Abdulaziz T, Sander W. The increasing challenge of epilepsy in the elderly: shortening hospital admission. Arq. Neuro-Psiquiatr. 2020; 78(11): 669-671.


    (2023). Sociodemographic and clinical characterization in hospital discharges of patients diagnosed with epilepsy Chile 2015-2019. Hospital discharges due to epilepsy in Chile.Journal of Neuroeuropsychiatry, 57(4).
    Recovered from 141
    2023. « Sociodemographic and clinical characterization in hospital discharges of patients diagnosed with epilepsy Chile 2015-2019. Hospital discharges due to epilepsy in Chile» Journal of Neuroeuropsychiatry, 57(4). 141
    (2023). « Sociodemographic and clinical characterization in hospital discharges of patients diagnosed with epilepsy Chile 2015-2019. Hospital discharges due to epilepsy in Chile ». Journal of Neuroeuropsychiatry, 57(4). Available in: 141 ( Accessed: 1diciembre2023 )
    Journal Of Neuropsichiatry of Chile [Internet]. [cited 2023-12-01]; Available from: